Correlation between the cre to TSS distance to corresponding gene expression level (fold change). (A) High-affinity cre boxes. (B) Low-affinity cre boxes. Black circles - cre boxes of the genes for which TSSs were detected experimentally; grey circles - cre boxes of the genes for which TSSs were predicted in this study, underlined gene names – genes with cre sites known from literature. “0” on the X ax represents the TSS position, negative numbers – cre boxes upstream TSS, positive numbers – cre boxes downstream TSS. For clarity, the outliers were removed (for the full list of cre-TSS distance, see Additional file 5).