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Figure 6 | BMC Genomics

Figure 6

From: H3K9 and H3K14 acetylation co-occur at many gene regulatory elements, while H3K14ac marks a subset of inactive inducible promoters in mouse embryonic stem cells

Figure 6

Differential H3K14ac over inactive promoters as compared to H3K9ac. (A) Heatmap representing the correlation between total H3, H3K9ac, H3K14ac, H3K4me3, H3K27ac, H3K27me3 and H3K9me3 around the TSS (-/+ 2 kb). Active promoter marks; H3K14ac, H3K9ac, H3K4me3 and H3K27ac clustered separately (blue square) to form an active promoter chromatin state. Inactive marks (H3K9me3 and H3K27me3) have higher co-occurrence with H3K14ac as compared to H3K9ac (red square) (B) Ratio of H3K14ac/H3K9ac ChIP-seq tag density plotted for active promoters and inactive promoters. Ratio is significantly higher for inactive promoters suggesting that level of H3K14ac is higher over inactive promoters as compared to H3K9ac.

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BMC Genomics

ISSN: 1471-2164

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