Table 5 Summary of supporting evidence for primary candidates examined in experiment 2
From: Identification of novel candidate genes for follicle selection in the broiler breeder ovary
Gene | QPCR P value | BioLayout Profile | QTL Chromosome | AL vs. FR (Predicted) | Literature |
|---|---|---|---|---|---|
FSHR | 0.001 | Key mediator of reproductive signalling | |||
TGFBR1 | <0.001 | Key mediator of cell growth + survival | |||
SMAD3 | <0.001 | Promotes Cell Survival | |||
SLIT3 | 0.001 | Gga13 | Up | Promotes Apoptosis | |
PDGFRL | <0.001 | Down 5–8 mm | Up | Homologs involved in steroidogenesis | |
VDAC1 | <0.001 | Up in 5–8 mm | Gga13 | Up | Central to pro-apoptotic signalling |
YAP1 | <0.001 | Up in 5–8 mm | Up | Possible pro-cell survival signalling | |
MOSPD1 | <0.001 | Clustered with FSHR | Up-regulated in ovarian cancer | ||
KRT75 | <0.001 | Down 5–8 mm | Possible Lipid Transport | ||
SPTY2D1 | <0.001 | Up in 5–8 mm | Down | Unknown | |
RIGG1740 | 0.017 | Up in 5–8 mm | Down | Unknown | |
GULP1 | <0.001 | Up in 5–8 mm | Up | Phagocytosis of apoptotic cells |