Table 4 Functional Annotation Clustering of statistically-significant over-expressed genes in European eel silver males from the river Tiber site (N = 8) in comparison with silver males from the lake Bolsena site (N = 7)

Annotation Cluster 1

Cytochrome c oxidase subunit 1

(Enrichment Score: 1.81)

Cytochrome P450, family 2 subfamily J, polypeptide 23 (CYP2J23)

Cytochrome P450, family 3 subfamily A, polypeptide 65 (CYP3A65)

Cytochrome P450, family 46 subfamily A, polypeptide 61 (CYP46A1)

Glutamate dehydrogenase 1a

Glutathione peroxidase 1a

Retinol saturase (all-trans-retinol 13,14-reductase)

SH3 domain binding glutamic acid-rich protein like 3

Sulfide quinone reductase-like

Transferrin-a, Rho-class gluthatione S-transferase

Annotation Cluster 2

Pi-class glutathione-S-transferase

(Enrichment Score: 1.53)

Glutathione peroxidase 1a

SH3 domain binding glutamic acid-rich protein like 3

Transferrin receptor 1a

Transferrin -a: Rho-class glutathione-S-transferase