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Table 1 Top 25 genes co-expressed with aging related genes

From: GeneFriends: An online co-expression analysis tool to identify novel gene targets for aging and complex diseases

Gene Previous association evidence Reference
Thbs1 Plays a role in platelet aggregation, angiogenesis and tumorigenesis [5759]
Ctsh No previous associations  
2310043n10rik No previous associations  
Sat1 Induction has been suggested as a therapeutic strategy for treating colorectal cancer [60]
Tcn2 No previous associations  
Pgcp No previous associations  
D12ertd647e No previous associations  
Cd74 Initiates signalling leading to cell proliferation and survival [61]
B2m B2m deficient mice suffer from tissue iron overload [62]
Tgm2 Overexpression increases apoptosis in neuroblastoma cells [63]
Implicated in fibrosis, neurodegenerative and celiac disease [64]
Rarres2 No previous associations  
Anxa1 Plays an important role in anti-inflammatory signalling, apoptosis and proliferation [65, 66]
Il10rb No previous associations  
Ctsc Mutations cause Papillon-Lefevre Disease [67, 68]
Lipa Mutations can cause Cholesteryl ester storage disease and Wolman disease [69]
IL3ra1 No previous associations  
Lgals3bp Associated with cancer and metastasis [70]
Pros1 Associated with Thrombosis [71, 72]
Fcgr2b No previous associations  
Scd1 Plays an important role in body weight regulation and development of obesity [73]
Ifi35 No previous associations  
Ctla2b No previous associations  
Cebpd Implicated in adipocyte differentiation, learning and memory, mammary epithelial cell growth control. [7476]
Loss of Cebpd leads to chromosome instability [77]
Fcgrt No previous associations  
H2-t23 No previous associations  
  1. For a full list refer to Additional file 3.