Table 1 Top 25 genes co-expressed with aging related genes

Thbs1

Plays a role in platelet aggregation, angiogenesis and tumorigenesis

[57–59]

Ctsh

No previous associations

2310043n10rik

No previous associations

Sat1

Induction has been suggested as a therapeutic strategy for treating colorectal cancer

[60]

Tcn2

No previous associations

Pgcp

No previous associations

D12ertd647e

No previous associations

Cd74

Initiates signalling leading to cell proliferation and survival

[61]

B2m

B2m deficient mice suffer from tissue iron overload

[62]

Tgm2

Overexpression increases apoptosis in neuroblastoma cells

[63]

Implicated in fibrosis, neurodegenerative and celiac disease

[64]

Rarres2

No previous associations

Anxa1

Plays an important role in anti-inflammatory signalling, apoptosis and proliferation

[65, 66]

Il10rb

No previous associations

Ctsc

Mutations cause Papillon-Lefevre Disease

[67, 68]

Lipa

Mutations can cause Cholesteryl ester storage disease and Wolman disease

[69]

IL3ra1

No previous associations

Lgals3bp

Associated with cancer and metastasis

[70]

Pros1

Associated with Thrombosis

[71, 72]

Fcgr2b

No previous associations

Scd1

Plays an important role in body weight regulation and development of obesity

[73]

Ifi35

No previous associations

Ctla2b

No previous associations

Cebpd

Implicated in adipocyte differentiation, learning and memory, mammary epithelial cell growth control.

[74–76]

Loss of Cebpd leads to chromosome instability

[77]

Fcgrt

No previous associations

H2-t23

No previous associations