Table 2 Summary of miR-181b correlation analyses for canonical and non-canonical miRNA-mRNA outcomes

miR

R²: 0.995; p<0.0001

R²: 1.000; p<0.0001

R²: 0.976; p<0.0001

anti-miR

R²: 0.994; p<0.0001

R²: 1.000; p<0.0001

R²: 0.985; p<0.0001

Bidirectional

R²: 1.000; p<0.0001

R²: 1.000; p<0.0001

R²: 0.970; p<0.0001

Cell Type

HEK-293

R²: 0.996, p<0.0001

R²: 1.000, p<0.0001

R²: 0.988, p<0.0001

HeLa

R²: 0.996, p<0.0001

R²: 1.000, p<0.0001

R²: 0.983, p<0.0001

SH-SY5Y

R²: 1.000, p<0.0001

R²: 1.000, p<0.0001

R²: 0.989, p<0.0001

Conservation

Conserved

R²: 0.986, p<0.0001

R²: 0.751, p=0.0196

R²: 0.193, p=0.6183

Non-Conserved

R²: 0.959, p<0.0001

R²: 0887, p=0.0014

R²: 0.835, p=0.0051

Seed Sequence

8mer

R²: 0.981, p<0.0001

R²: 0.803, p=0.0091

R²: 0.803, p=0.0092

7mer-m8

R²: 0.970, p<0.0001

R²: 0.853, p=0.0034

R²: 0.790, p=0.0112

7mer-1A

R²: 0.975, p<0.0001

R²: 0.780, p=0.0131

R²: 0.782, p=0.0127