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Table 2 Overlaps (%) of EIs with chromatin marks a

From: Euchromatin islands in large heterochromatin domains are enriched for CTCF binding and differentially DNA-methylated regions

 

EIs overlap with

Observed

Random within LOCKs

Fold enrichedc

P valueb

Random at WG

Fold enrichedc

P valueb

HAEC

CTCF

61.3

4.4

13.9

<10-3

7.5

8.2

<10-3

DHSs

48.9

10.1

4.8

<10-3

7.5

6.5

<10-3

H3K4me3

23.3

6.8

3.4

<10-3

5.6

4.2

<10-3

H3K27me3

46.0

34.1

1.4

<10-3

27.8

1.7

<10-3

H3K36me3

20.0

14.1

1.4

<10-3

9.7

2.1

<10-3

H3K9ac

17.7

6.0

2.9

<10-3

5.3

3.3

<10-3

H1

CTCF

46.9

9.0

5.2

<10-3

11.8

4.0

<10-3

DHSs

36.0

7.1

5.1

<10-3

18.1

2.0

<10-3

H3K4me3

13.2

1.8

7.4

<10-3

1.4

9.8

<10-3

H3K27me3

21.6

10.8

2.0

<10-3

9.8

2.2

<10-3

H3K36me3

11.0

16.1

0.7

1

15.2

0.7

1

H3K9ac

28.9

11.8

2.4

<10-3

11.5

2.5

<10-3

HPF

CTCF

56.9

7.9

7.2

<10-3

9.6

5.9

<10-3

DHSs

71.0

27.7

2.6

<10-3

19.2

3.7

<10-3

H3K4me3

30.8

8.1

3.8

<10-3

13.0

2.4

<10-3

H3K27me3

53.1

34.2

1.6

<10-3

29.0

1.8

<10-3

H3K36me3

22.6

16.5

1.4

<10-3

24.9

0.9

0.85

H3K9ac

13.2

2.5

5.2

<10-3

6.2

2.1

<10-3

  1. a EIs of HAEC, H1 and HPF were compared with chromatin marks of HUVEC, H1 and normal lung fibroblasts, respectively (ref.10).
  2. bP values were calculated by 1000 permutations.
  3. cEnrichment is calculated as the ratio of observed to random.