Table 1 Characteristic phenotypes of HAB vs. LAB mice (F0 mice, N = 8 per gender and line); values are represented as mean ± standard error of means (SEM); corrected p-values refer to Bonferroni correction and are sorted by p-values of comparison in male mice

EPM - percent time on the open arm

4±1

74±2

0.0000

0.0000

6±1

61±6

0.0000

0.0011

EPM - percentage of open arm entries

17±2

63±4

0.0000

0.0000

20±3

53±6

0.0005

0.0115

TST - total immobility time [s]

113±10

4±1

0.0000

0.0002

112±11

7±3

0.0000

0.0010

EPM - closed arm entries

19±1

8±1

0.0000

0.0007

19±1

10±2

0.0020

0.0510

EPM - full open arm entries

0±0

13±2

0.0002

0.0049

0±0

9±1

0.0002

0.0060

EPM - open arm entries

4±1

13±2

0.0016

0.0461

5±1

11±2

0.0102

0.2555

TST - latency to 1st immobility [s]

101±5

232±28

0.0023

0.0633

105±12

235±40

0.0137

0.3423

PHYS - total fluid intake [ml]

6±1

11±1

0.0027

0.0746

NA

NA

NA

NA

OF - total distance travelled [m]

9±2

24±4

0.0042

0.1180

14±2

29±2

0.0003

0.0078

PHYS - daily water intake [ml/g]

0.22±0.03

0.36±0.03

0.0044

0.1231

NA

NA

NA

NA

PHYS - urine osmolality [osmol/kg]

2.9±0.2

2.3±0.2

0.0164

0.4595

NA

NA

NA

NA

EPF - frequency of head dips

4±2

12±3

0.0313

0.8760

4±2

14±6

0.1914

1.0000

HPA-RT - increase in CORT [μg/l]

110±16

163±18

0.0360

1.0000

187±27

254±26

0.0995

1.0000

EPM - latency to 1st open arm entry [s]

87±24

27±5

0.0391

1.0000

118±30

52±12

0.0702

1.0000

EPF - latency to 1st head dip [s]

138±42

33±13

0.0420

1.0000

138±48

110±61

0.7244

1.0000

HPA-RT - stress CORT [μg/l]

118±13

165±15

0.0499

1.0000

207±23

260±20

0.1018

1.0000

EPF - total grooming time [s]

0.84±0.84

4.79±1.77

0.0765

1.0000

1±1

1.25±1.25

0.8789

1.0000

FST - total swimming time [s]

111±25

168±20

0.0994

1.0000

184±27

187±38

0.9448

1.0000

FST - total floating time [s]

165±24

118±21

0.1548

1.0000

128±28

119±34

0.8423

1.0000

OF - total time in the inner zone [s]

7±2

3±2

0.2047

1.0000

6±4

11±4

0.4170

1.0000

EPF - frequency of grooming

0.3±0.3

0.9±0.4

0.2297

1.0000

0.3±03

0.5±0.5

0.6674

1.0000

FST - latency to 1st floating [s]

110±7

95±10

0.2469

1.0000

96±5

121±16

0.1768

1.0000

HPA-RT - basal CORT [μg/l]

6.8±2.5

4.3±0.8

0.3724

1.0000

19±13

11±7

0.6019

1.0000

OF - entries to the inner zone

5.5±2.5

3.1±1.8

0.4510

1.0000

6.8±2.8

8.5±3.5

0.6991

1.0000

EPM - all arm entries

23±2

21±3

0.4732

1.0000

24±2

21±3

0.3112

1.0000

FST - total struggling time [s]

87±9

80±9

0.5799

1.0000

52±7

58±8

0.6015

1.0000

PHYS - body weight [g]

29±1

29±1

0.6776

1.0000

22±1

24±1

0.1141

1.0000

EPM - sum of total arm entries

23±2

21±3

0.4600

1.0000

24±2

21±3

0.5610

1.0000