Heatmap of 53 genes commonly differentially regulated across all three species infected with CA04 virus. Average log10(ratio) expression of 53 DE genes induced by CA04 virus. In mice and swine, infected lung gene expression is referenced to specie-matched mock at each time point. In macaques, infected lung gene expression is relative to an uninfected lung reference pool at each time point. Red indicates expression was increased relative to the control reference and green indicates that expression was decreased relative to the control reference. Saturation is 4-fold. A total of 22 DE genes associated with inflammatory response are highlighted on the right; yellow denotes positive association.