Immune genes exhibit unique expression profiles in mice, macaques, and swine infected with CA04 virus. Average log10(ratio) expression of DE genes induced by CA04 virus. In mice and swine, infected lung gene expression is referenced to specie-matched mock at each time point. In macaques, infected lung gene expression is relative to an uninfected lung reference pool at each time point. Red indicates expression was increased relative to the control reference and green indicates that expression was decreased relative to the control reference. Saturation is 4-fold. There are a total of 16 DE genes represented for Communication between Innate and Adaptive Immune Cells, 28 DE genes represented for Acute Phase Response Signaling, 31 DE genes represented for LXR/RXR Activation, and 12 DE genes represented for VDR/RXR Activation. The association of each DE gene within a given species for each of the represented Canonical Pathways is shown on the left; blue denotes differential expression and gray denotes no differential expression. The following abbreviations are used: Mm, Mus musculus (mouse); Mf, Macaca fascicularis (macaque); and Ss, Sus scrofa (swine).