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Table 1 Canonical Pathways enriched in mouse, macaque and swine CA04 infection models

From: 2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models

Infection model Canonical pathway B-H p- value mola/molb
Mouse Acute Phase Response Signaling 2.34E-10 28/177
  LXR/RXR Activation 2.34E-10 26/136
  Atherosclerosis Signaling 3.47E-09 22/129
  Hepatic Fibrosis / Hepatic Stellate Cell Activation 6.31E-07 21/147
  IL-12 Signaling and Production in Macrophages 1.12E-06 20/155
  Complement System 4.07E-06 10/35
  Type I Diabetes Mellitus Signaling 5.50E-06 17/121
  Nitrogen Metabolism 8.51E-05 9/120
  Clathrin-mediated Endocytosis Signaling 1.30E-04 20/195
  Dendritic Cell Maturation 1.70E-04 18/185
Macaque VDR/RXR Activation 3.63E-03 13/81
  Hematopoiesis from Pluripotent Stem Cells 5.25E-03 10/64
  Communication between Innate and Adaptive Immune Cells 2.75E-02 12/109
  Type I Diabetes Mellitus Signaling 3.16E-02 13/121
  Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 3.80E-02 11/92
  Gα12/13 Signaling 3.80E-02 13/127
  Neuroprotective Role of THOP1 in Alzheimer's Disease 3.80E-02 7/54
  Hematopoiesis from Multipotent Stem Cells 3.80E-02 4/12
  Primary Immunodeficiency Signaling 3.80E-02 8/63
  Pyrimidine Metabolism 3.80E-02 14/215
Swine LXR/RXR Activation 1.15E-07 20/136
  Nitrogen Metabolism 9.33E-04 8/120
  Antigen Presentation Pathway 9.33E-04 8/40
  Communication between Innate and Adaptive Immune Cells 9.33E-04 12/109
  Hepatic Fibrosis / Hepatic Stellate Cell Activation 9.33E-04 15/147
  Type I Diabetes Mellitus Signaling 9.33E-04 13/121
  Primary Immunodeficiency Signaling 9.33E-04 9/63
  Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses 9.33E-04 12/106
  TREM1 Signaling 9.33E-04 9/66
  Atherosclerosis Signaling 1.12E-03 13/129
  1. Ingenuity Pathway Analysis was used to determine the top 10 Canonical Pathways. Benjamini-Hochberg (B-H) Multiple Testing Correction p-value was used to rank the significance associated for each pathway.
  2. a Number of molecules differentially expressed in the Canonical Pathway.
  3. b Total number of molecules in the annotated Canonical Pathway.