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Table 4 Experimentally validated miRNA-related SNPs found in MirSNP

From: MirSNP, a database of polymorphisms altering miRNA target sites, identifies miRNA-related SNPs in GWAS SNPs and eQTLs

MiRNA Target gene Functional SNP Reported associated disease MirSNP PolymiRTS2 Mirsnpscore Patrocles Pubmed id Journal Author
hsa-mir-629 NBS1 rs2735383 Lung cancer      22114071 Carcinogenesis Yang L
hsa-mir-184 TNFAIP2 rs8126 Squamous cell carcinoma of the head and neck    21934093 Carcinogenesis Liu Z
hsa-mir-1827 MYCL1 rs3134615 Small-cell lung cancer   21676885 Cancer Res Xiong F
hsa-mir-148a HLA-C rs67384697 HIV     21499264 Nature Kulkarni S
hsa-mir-191 MDM4 rs4245739 Ovarian carcinomas     21084273 Cancer Res Wynendaele J
hsa-mir-125b BMPR1B rs1434536 Breast cancer 19738052 Cancer Res Saetrom P
hsa-mir-510 HTR3E rs56109847 Diarrhea predominant irritable bowel syndrome    18614545a Hum. Mol. Genet Kapeller J
hsa-mir-96 HTR1B rs13212041 Arson or property damage      18283276a Mol. Psychiatry Jensen KP
hsa-mir-433 FGF20 rs12720208 Parkinson’s disease     18252210a Am. J. Hum. Genet Wang G
hsa-mir-148/152 HLA-G rs1063320 Childhood asthma 17847008a Am. J. Hum. Genet Tan Z
hsa-mir-24 DHFR rs34764978 Methotrexate resistance      17686970a PNAS Mishra PJ
hsa-mir-155 AGTR1 rs5186 Hypertension    17668390a Am. J. Hum. Genet Sethupathy P
hsa-mir-206 ESR1 rs9341070 Breast cancer      17312270a Mol. Endocrinol Adams BD
hsa-mir-24 SLITRK1 rs193302862 Tourette’s syndrome     16224024a Science Abelson JF
  1. Some cases are not in MirSNP because the SNPs were not located in the 3’UTR based on our records (rs34764978, rs13212041) or do not have a perfect 7-nt binding in the seed site (rs2735383, rs9341070).
  2. aThese cases are from Table 2 in Sethupathy and Collins [34].