Figure 5

Correlation patterns of allele-specificity among different TFs and HMs in GM12878 cells discovered by iASeq. (a) The BIC values for different class number K. The BIC achieves the minimum at K=2. (b) The estimated V and W when K=2. Each row corresponds to a class. Each column represents a dataset. The color in the cell (k,d) represents the SR or SN probability in class k and dataset d. From white to dark, the probability increases from 0 to 1. The bar plot and the numbers shown under Π are the estimated number of SNPs in each class (i.e., ${\widehat{\Pi }}_k\ast$ the total number of SNPs). The bar plot and the numbers shown under a _i are the number of SNPs identified for the corresponding class using the posterior probability Pr(a _i =k|X _i ,N _i ,Π,V,W)>0. 9 as cutoff. (c) A closer look at V and W in a number of representative datasets. The barplots show the estimated SR and SN probabilities v _kd and w _kd in a number of selected datasets. Left: the skewing probabilities in class 1. Right: the skewing probabilities in class 2. The height of each bar represents the SR or SN probability.