Insights into the regulation of human CNV-miRNAs from the view of their target genes

BMC Genomics

Table 1 Simulation analysis to explore the target-recognition preference of CNV-miRNAs and non-CNV-miRNAs

	The numberof regulatory miRNAs	Mean of 1,000 simulations	Std. dev of 1,000 simulations	Observed number	p-values
Genes regulated exclusively by CNV miRNAs	1 CNV-miRNA	716.479	67.633	823	0.0576
	2 CNV-miRNAs	134.428	22.810	211	0.000392
	3 CNV-miRNAs	28.597	8.115	67	0.000001
	4 CNV-miRNAs	7.119	3.421	22	0.000006
	≥5 CNV-miRNAs	2.809	1.846	11	0.0000004
Genes regulated exclusively by non-CNV miRNAs	1 non-CNV-miRNA	1514.503	67.633	1,408	0.0576
	2 non-CNV-miRNAs	609.760	45.420	515	0.0184
	3 non-CNV-miRNAs	277.837	31.374	207	0.0119
	4 non-CNV-miRNAs	145.793	22.981	95	0.0135
	≥5 non-CNV-miRNAs	185.483	42.717	105	0.0297

The p-values were obtained from the Z-score, which was calculated as (observed number – mean number of 1000 simulations) / standard deviation of 1000 simulations.

ISSN: 1471-2164