Skip to main content

Advertisement

Table 2 Time-dependent elicitation of cytokine and signaling pathway by TSA in H9c2 cells*

From: Pan-histone deacetylase inhibitors regulate signaling pathways involved in proliferative and pro-inflammatory mechanisms in H9c2 cells

Control versus TSA (6 h) Control versus TSA (24 h)
Gene pathway Total connections (No. of focus genes) Gene pathway Total connections (No. of focus genes)
TGFβ1 33 (16) TGFβ1 29 (18)
HNF4A 30 (14) HNF4A 30 (12)
MyC 30 (12) ERK-p38-JNK 56 (10)
PTEN-PI3K-Akt 53 (11) TP53 33 (10)
TNF-α 35 (10) TNF-.α 30 ( 8 )
NFκΒ 33 (10) FOS 28 ( 8 )
p38-JNK 45 ( 9 ) CDKN1A 12 ( 8 )
IFNγ 32 ( 9 ) NFκΒ 29 ( 3 )
Caspase 3 28 ( 8 ) Calcium 28 ( 3 )
CDKN2A 10 ( 8 ) AP1 18 ( 3 )
Calcium 31 ( 6 ) CaMKII 10 ( 3 )
Insulin 22 ( 6 ) Caspase 3 16 ( 2 )
TP53 20 ( 5 )   
  1. *DEGs in response to TSA treatment of H9c2 cells for 6 and 24 h were subject to IPA as detailed in “Material and Methods”. Gene pathways with total number of connections (direct and indirect) and focus genes are hierarchically arranged according to the number of focus genes. The relative order of the p53-specific network elicited at 6 h (13th) and 24 h (4th) is mechanistically significant.