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Table 3 Key cytokine and signaling pathway elicited in response to CBHA at 6h and 24h in H9c2 cells*

From: Pan-histone deacetylase inhibitors regulate signaling pathways involved in proliferative and pro-inflammatory mechanisms in H9c2 cells

Control versus CBHA (6 h) Control versus CBHA (24 h)
Gene pathway Total connections (No. of focus genes) Gene pathway Total connections (No. of focus genes)
TNF 45 (22) CDKN1A 65 (35)
Myc 43 (18) TP53 60 (35)
HNF4A 32 (18) IL-6 50 (34)
PTEN-PI3K-Akt 76 (17) HNF4A 41 (30)
ERK-p38-JNK 73 (17) CDKN2A 43 (25)
NFκΒ 40 (16) ERK- p38-JNK 52 (21)
IFNγ 45 (12) NFκΒ 41 (17)
FOS 43 ( 8 ) IFNγ 38 (17)
AP1 31 ( 8 ) Cyclin A 29 (12)
Insulin 28 ( 8 ) PI3K-Akt 41 (10)
TP73 16 ( 7 ) MAPK 24 ( 8 )
CDKN2A 20 ( 5 ) Insulin 24 ( 5 )
  1. *DEGs in response to CBHA were subject to IPA as detailed in “Material and Methods”. Gene pathway with total number of connections (direct and indirect) and focus genes are hierarchically arranged according to the number of focus genes. The relative position of the p53-specific network elicited at 6 h (11th) and 24 h (2nd) is significant.