The arthritis severity locus Cia5a regulates the expression of inflammatory mediators including Syk pathway genes and proteases in pristane-induced arthritis

Table 6 Differentially expressed candidate genes located within the Cia5a interval on rat chromosome 10*

Gene Symbol	Gene name	Entrez Gene ID	Difference	p-value§
*Increased in DA*			*Fold DA/Cia5a*
Igsf7	immunoglobulin superfamily, member 7	287813	4.42	0.00008
Lgals3bp	lectin, galactoside-binding, soluble, 3 binding protein	245955	3.85	0.000001
RGD1309310	similar to mKIAA0195 protein	303677	3.89	0.00001
Sectm1b	secreted and transmembrane 1B	287884	7.61	0.00001
Slc16a3	solute carrier family 16, member 3	80878	5.36	0.000005
Sphk1	sphingosine kinase 1	170897	7.58	0.0000003
	*Increased in DA.F344(Cia5a)*		*Fold Cia5a/DA*
Itgb4	integrin beta 4	25724	2.85	0.0004
RGD1311422	similar to CG8841-PA	287822	2.57	0.002
RGD1561778	similar to dendritic cell-derived immunoglobulin(Ig)-like receptor 1, DIgR1	303666	2.77	0.002
Slc25a10	solute carrier family 25, member 10	170943	2.15	0.004
*Expressed only or predominantly in DA*			*Frequency DA:Cia5a*
Cd300lf	CD300 molecule-like family, member f	287818	6:0	0.0003
Fdxr	ferredoxin reductase	79122	6:1	0.0047
Cd7	CD7 molecule	303747	6:0	0.0003
Sectm1a	secreted and transmembrane 1A	287885	6:1	0.0047
*Expressed only or predominantly in DA.F344(Cia5a)*
Aanat	arylalkylamine N-acetyltransferase	25120	0:7	0.0047
Hrnbp3	hexaribonucleotide binding protein 3	287847	1:6	0.1♯

*List contains the most signficantly differentially expressed genes; § t-test was used to compare means for fold-difference calculations and Fisher's Exact test to compare frequencies. #not statistically significant.

ISSN: 1471-2164