Figure 2

Predictive performance and pairwise correlation of AAWS are higher for serum IgM than for monoclonal antibodies. (A) Predictive performance values were calculated for monoclonal (mAb) and serum IgM antibody (Sera IgM) binding profiles. (B) Shown is the pairwise correlation (r) of the corresponding AAWS ${\overrightarrow{w}}^j$. In both (A) and (B), mAb signifies antibody binding profiles from 13 monoclonal antibodies and Sera IgM binding profiles from 58 BALB/c mouse serum samples. Differences between monoclonal and serum IgM antibodies in predictive performance (Q²) and pairwise correlation (r) of AAWS are significant (p < 0.001). Antibody binding profiles were measured with the standard peptide library of 255 14-mers. Corresponding AAWS (${\overrightarrow{w}}^j$) were determined using Equation 1.