Table 2 List of significant pathways in the hippocampus of type 2 diabetic rats.

Insulin/GH secretion

GO:30073: insulin secretion

Gal

GO:30252: growth hormone secretion

Gal

Oxidative stress DNA damage cell cycle

GO:6950: response to stress

Gal

GO:305: response to oxygen radical

Cxcl4(Pf4)

GO:303: response to superoxide

Akap3

GO:302: response to reactive oxygen species

Gal

Nudt15_predicted

GO:15992: proton transport

Ucp2

GO:6977: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

Ptprv

GO:42770: DNA damage response, signal transduction

Ftcd

GO:7346: regulation of progression through mitotic cell cycle

Snf1lk

GO:6269: DNA replication, synthesis of RNA primer

NM_001008768 (Prim1)

GO:7089: traversing start control point of mitotic cell cycle

Cdk10

Lipid metabolism

GO:1573: ganglioside metabolism

Gm2a

GO:6695: cholesterol biosynthesis

Acaa2

Acaa2

Eating/feeding behavior

GO:7631: feeding behavior

Gal, Agrp

GO:42755: eating behavior

Agrp

Stat3

Development of the nervous system

GO:7399: nervous system development

Gal, Mobp, Mobp, Cntn3

Ednrb, RGD1311340_predicted, Stat3, XM_242005

GO:7422: peripheral nervous system development

Sncg

Ednrb

Others

GO:50776: regulation of immune response

Gal, Il22ra2

GO:6952: defense response

Mx2

GO:7194: negative regulation of adenylate cyclase activity

Grm2

GO:6032: chitin catabolism

Chi3l1

GO:42572: retinol metabolism

Retsat

GO:45123: cellular extravasation

Itgam

GO:19637: organophosphate metabolism

Pter

GO:6928: cell motility

Akap3, Grm2

Stat3

GO:9615: response to virus

Mx2, Oas1

XM_215121