Comparative genome analysis of K-10 and S397 MAP strains. (A) Comparison of the Bsi WI restriction maps between K-10 (inner circle) and S397 (outer circle). Each box represents a restriction fragment. Green boxes are regions in the same direction and red boxes are regions that are inverted between the two genomes. White boxes are fragments that are not aligned. The red thin line at 12 o'clock is the locus of the gene dnaA. (B) Mauve alignment of all 184 scaffolds of S397 (bottom) with the complete genome of K-10 (top). The colored boxes represent homologous regions present in each genome, which are also connected by lines. Blocks below the centerline of the S397 genome indicate regions with inverse orientation. Regions outside the blocks lack homology between the genomes. Within each block there is a similarity profile of the DNA sequences and the white areas indicate sequences specific to a genome. The scale is in base pairs.