Skip to main content

Table 2 Pathway analysis for 399 genes that reduced 128Q-neuron dysfunction when knocked-down by RNAi

From: Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons

Pathway P value Gene
Ascorbate and aldarate metabolism 0.00000 B0281.5, B0286.3, B0478.1/jnk-1, C06B3.4/stdh-1, C08E3.4/fbxa-161, C08F8.5/fbxb-9, C09G1.1/pqn-11, C10C5.4, C10C5.5, C10G11.5/pnk-1, C17G10.5/lys-8, C17H12.8, C39D10.7, C45B11.3/dhs-18, C46E10.7/srh-99, C54D10.3, D1054.10, D2045.6/cul-1, F07F6.1, F07F6.5/dct-5, F09B12.3, F17E5.1/lin-2, F28D1.5/thn-2, F29G9.1, F31C3.6, F36F2.1, F38E11.2/hsp-12.6, F38H4.8/ech-2, F41B5.4/cyp-33C3, F42G10.1, F43G9.5, F44D12.8, F47C10.2/btb-21, F52H3.5, F53C3.5, F56D5.5, F56G4.3/pes-2.2, F57C9.4, F57H12.7/mec-17, H04M03.1, H10D18.2/scl-12, K02B12.2, K02E11.5, K10B3.8/gpd-2, M01E11.2, M02D8.4, R03E9.1/mdl-1, R05F9.10/sgt-1, R12B2.5/mdt-15, R12H7.2/asp-4, T03F6.1/qdpr-1, T17H7.1, T20B5.3/oga-1, T21C9.8/ttr-23, T22G5.2/lbp-7, T24B8.5, W02D3.1, W03D2.6, W05H9.1, Y106G6H.7/sec-8, Y106G6H.9, Y38H6C.1/dct-16, Y43C5B.2, Y47D3B.7/sbp-1, ZK1127.10, ZK1290.6/rnh-1.1, ZK384.2/scl-20, ZK520.4/cul-2, ZK550.6, ZK637.8/unc-32, ZK829.6/tgt-1
Sulfate assimilation 0.00001 B0218.3/pmk-1, B0412.2/daf-7, B0478.1/jnk-1, C47G2.2/unc-130, C53D6.2/unc-129, F38A6.1/pha-4, F43C1.2/mpk-1, T23H2.5/rab-10, Y11D7A.4/rab-28
Pyrimidine metabolism 0.00113 B0304.1/hlh-1, B0478.1/jnk-1, B0547.1/csn-5, C04E7.2/sor-3, C07B5.5/nuc-1, C25D7.3/sdc-3, C34E10.7/cnd-1, C37A2.4/cye-1, C47G2.2/unc-130, F14F3.1/vab-3, F38A6.1/pha-4, F56A8.7/unc-64, K01G5.2/hpl-2, Y47D3A.6/tra-1, ZK520.4/cul-2
Pyridoxal phosphate salvage pathway 0.00176 B0218.3/pmk-1, B0478.1/jnk-1, F43C1.2/mpk-1, Y18D10A.5/gsk-3, Y38F1A.10/max-2
Oxytocin receptor mediated signaling 0.00236 B0478.1/jnk-1, B0547.1/csn-5, C44H4.6, F43C1.2/mpk-1, Y11D7A.4/rab-28, Y18D10A.5/gsk-3
Interferon-gamma signaling 0.00251 B0218.3/pmk-1, B0478.1/jnk-1, F43C1.2/mpk-1
Glycosphingolipid biosynthesis - ganglio series 0.00297 T14F9.3/hex-1, T26C5.3
Cyanoamino acid metabolism 0.00340 B0035.8/his-48, B0304.1/hlh-1, B0478.1/jnk-1, B0547.1/csn-5, C02B8.4/hlh-8, C04E7.2/sor-3, C07B5.5/nuc-1, C09G9.7, C18A3.1, C25A1.11/aha-1, C25D7.3/sdc-3, C29F9.5, C34E10.7/cnd-1, C37A2.4/cye-1, C47G2.2/unc-130, F11A10.1/lex-1, F14F3.1/vab-3, F22D3.1/ceh-38, F22F1.1/hil-3, F38A6.1/pha-4, F45F2.4/his-7, F54C8.2/cpar-1, F56A8.7/unc-64, K01G5.2/hpl-2, K02B9.4/elt-3, R03E9.1/mdl-1, R05F9.10/sgt-1, R07B1.1/vab-15, R13H8.1/daf-16, T05A6.1/cki-1, T19B10.11/mxl-1, T27F2.1/skp-1, W06E11.1, Y39B6A.2/pph-5, Y47D3A.6/tra-1, Y47D3B.7/sbp-1, Y49E10.1/rpt-6, Y57E12AL.5/mdt-6, ZC204.2, ZK131.7/his-13, ZK520.4/cul-2, ZK652.5/ceh-23
Taurine/hypotaurine metabolism 0.00348 F56A8.7/unc-64, K02D10.5, T10H9.3, Y22F5A.3/ric-4
Glycolysis/Gluconeogenesis 0.00365 AC3.7/ugt-1, C05C8.3/fkb-3, C06B3.4/stdh-1, C07B5.5/nuc-1, F11A5.12/stdh-2, F38E11.2/hsp-12.6, K10B3.8/gpd-2, R03E9.1/mdl-1, R12B2.5/mdt-15, R13H8.1/daf-16, T22G5.2/lbp-7, T28B8.2/ins-18
Selenocompound metabolism 0.00365 AC3.7/ugt-1, C05C8.3/fkb-3, C06B3.4/stdh-1, C07B5.5/nuc-1, F11A5.12/stdh-2, F38E11.2/hsp-12.6, K10B3.8/gpd-2, R03E9.1/mdl-1, R12B2.5/mdt-15, R13H8.1/daf-16, T22G5.2/lbp-7, T28B8.2/ins-18
Insulin_IGF pathway-protein kinase B signaling cascade 0.00404 C44H4.6, C47G2.2/unc-130, F38A6.1/pha-4, Y18D10A.5/gsk-3
Salvage pyrimidine ribonucleotides 0.00417 F42G9.7/snt-2, K02D10.5, Y22F5A.3/ric-4
Tetrahydrofolate biosynthesis 0.00417 B0218.3/pmk-1, B0478.1/jnk-1, F43C1.2/mpk-1
Apoptosis signaling 0.00503 B0218.3/pmk-1, B0478.1/jnk-1, F43C1.2/mpk-1, Y18D10A.5/gsk-3, Y38F1A.10/max-2
Glycosaminoglycan degradation 0.00520 K09E4.4, T14F9.3/hex-1
Angiogenesis 0.00520 C06B3.4/stdh-1, F11A5.12/stdh-2, K04A8.5
mRNA splicing 0.00534 F56A8.7/unc-64, K02D10.5, Y22F5A.3/ric-4, Y48B6A.8/ace-3
Muscarinic acetylcholine receptor 1 and 3 signaling 0.00608 F56A8.7/unc-64, K02D10.5, Y22F5A.3/ric-4, Y48B6A.8/ace-3
Alanine biosynthesis 0.00769 K02D10.5, K08F8.4/pah-1, Y22F5A.3/ric-4
Butanoate metabolism 0.00777 C06B3.4/stdh-1, F11A5.12/stdh-2, K03A1.5/sur-5, T02G5.7
5-Hydroxytryptamine biosynthesis 0.00798 K02D10.5, Y22F5A.3/ric-4
Interleukin signaling 0.00974 C47G2.2/unc-130, F38A6.1/pha-4, F43C1.2/mpk-1, Y18D10A.5/gsk-3
Amino sugar and nucleotide sugar metabolism 0.01084 C01F1.3, C53B4.7/bre-1, K08E3.5, T14F9.3/hex-1
Metabotropic glutamate receptor group II pathway 0.01254 F56A8.7/unc-64, K02D10.5, Y22F5A.3/ric-4
Linoleic acid metabolism 0.01511 C06B3.4/stdh-1, F11A5.12/stdh-2
Beta3 adrenergic receptor signaling 0.01511 K02D10.5, Y22F5A.3/ric-4
Integrin signaling 0.01742 B0218.3/pmk-1, B0478.1/jnk-1, C27B7.8/rap-1, C36B1.1/cle-1, F43C1.2/mpk-1
p53 pathway by glucose deprivation 0.01908 C47G2.2/unc-130, F38A6.1/pha-4, F48E8.1/lon-1, Y18D10A.5/gsk-3
5-Hydroxytryptamine degredation 0.01939 K02D10.5, Y22F5A.3/ric-4
Ornithine degradation 0.02121 B0218.3/pmk-1, B0478.1/jnk-1, T19B10.11/mxl-1
Cortocotropin releasing factor receptor signaling 0.02412 K02D10.5, Y22F5A.3/ric-4
FGF signaling 0.02627 B0218.3/pmk-1, B0478.1/jnk-1, F26E4.1/sur-6, F43C1.2/mpk-1
N-acetylglucosamine metabolism 0.02712 F56A8.7/unc-64, K02D10.5, T02C12.1/hum-5, Y22F5A.3/ric-4, Y48B6A.8/ace-3
5HT3 type receptor mediated signaling 0.02928 K02D10.5, Y22F5A.3/ric-4
B cell activation 0.02939 B0218.3/pmk-1, B0478.1/jnk-1, F43C1.2/mpk-1
Fructose and mannose metabolism 0.03565 C06B3.4/stdh-1, C53B4.7/bre-1, F11A5.12/stdh-2
Pantothenate and CoA biosynthesis 0.04074 F25H9.6, T04G9.4
Alzheimer disease-amyloid secretase pathway 0.04074 K02D10.5, Y22F5A.3/ric-4
Beta1 adrenergic receptor signaling 0.04074 K02D10.5, Y22F5A.3/ric-4
Beta2 adrenergic receptor signaling 0.04074 K02D10.5, Y22F5A.3/ric-4
EGF receptor signaling 0.04229 B0218.3/pmk-1, B0478.1/jnk-1, C27B7.8/rap-1, F43C1.2/mpk-1
Toll receptor signaling 0.04494 C08B6.9/aos-1, F11A10.1/lex-1, F40G9.3/ubc-20, Y49E10.1/rpt-6
Alanine, aspartate and glutamate metabolism 0.04494 C04E7.2/sor-3, C34E10.7/cnd-1, C47G2.2/unc-130, F57H12.7/mec-17
Serine glycine biosynthesis 0.04620 B0478.1/jnk-1, F43C1.2/mpk-1, Y38F1A.10/max-2
Lysine biosynthesis 0.04869 C25A11.4/ajm-1, C36B1.1/cle-1, F17E5.1/lin-2, F22B5.1/evl-20, F43C9.4/mig-13, F56A8.7/unc-64, Y22F5A.3/ric-4
  1. Pathway analysis was based on hypergeomeric tests using pathways from Wormbook, KEGG and Panther. P < 0.05 was considered significant and results are shown by increasing P values.