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Table 2 Summary of predicted tissue-specific TF pairs with 3 most significant TF pairs in 22 human tissues

From: Detection of interacting transcription factors in human tissues using predicted DNA binding affinity

Tissue # interactions (nonsimilar) # factors Top three nonsimilar interactions Hubs
Bladder* 3 (3) 3 ELK1:NFYA, ELK1:NOBOX, NFYA:NOBOX -
Blood 6 (4) 5 SPI1:ARID3A, SPIB:ARID3A, SPI1:CTCF ARID3A, SPI1, SPIB
Bone 24 (24) 25 TBP:TFAP2A, TBP:EWSR1-FLI1, TBP:NOBOX TBP
Brain 25 (17) 20 SP1:SOX10, SP1:ESR2, SP1:REST MZF1, SP1
Cervix 40 (30) 24 ZFP423:ZFX, ELK1:ZFX, MIZF:ZFX ZFX, KLF4, ZFP423
Eye* 4 (2) 6 T:HNF1B, SP1:TAL1-TCF3 SP1
Heart* 6 (5) 7 MEF2A:MAFB, MEF2A:NFKB1, MEF2A:REST MEF2A
Kidney 95 (87) 64 GATA1:HNF1A, HNF1A:ARID3A, TP53:HNF1B HNF1A, HNF1B
Liver 106 (99) 67 HNF1A:HNF1B, HNF1A:HNF4A, HNF1A:CEBPA HNF1A, HNF1B
Lymph node 64 (57) 65 SPI1:MZF1, SPI1:MYF, SPI1:FOXQ1 SPI1
Muscle 41 (38) 40 MEF2A:ZFP423, MEF2A:NHLH1, MEF2A:NFIC MEF2A, TBP
Pancreas* 14 (13) 15 AR:TAL1-GATA1, MZF1:TAL1-GATA1, E2F1:TAL1-GATA1 TAL1-GATA1
Placenta* 2 (2) 4 RREB1:PDX1, ESRRB:POU5F1 -
PNS* 1 (0) 2 ELK4:REL -
Sm. intestine* 1 (1) 2 NFYA:TBP -
Stomach* 7 (6) 8 EWSR1-FLI1:PLAG1, MYC:PLAG1, PAX6:PLAG1 PLAG1
Testis* 16 (14) 19 FOXC1:HOXA5, ARNT-AHR:NOBOX, ARNT-AHR:NKX2-5 ARNT-AHR
Tongue* 12 (11) 16 NFKB1:NFIL3, NFKB1:TFAP2A, GATA3:NKX3-1 NFKB1
Adipose** 104 (90) 46 MZF1:NFYA, NFYA:MYB, NFYA:TBP NFYA, MZF1
Lymphocyte** 181 (156) 107 ELK1:CEBPA, ELK1:FOXA2, ELK1:POU5F1 NFYA, ELK1, GABPA
Hematop. SC** 50 (41) 36 ELK1:NFYA, NFYA:GABPA, ELK1:EGR1 NFYA, ELK1
Retinal pigm. epithelium** 259 (219) 116 ARNT-AHR:CREB1, ARNT-AHR:NFYA, CREB1:BRCA1 CREB1, NFYA, PAX2
  1. * Network predicted with p ≤ 10-5, ** network predicted with p < 10-10.
  2. Summary of predicted tissue-specific TF pairs (with p-value ≤ 10-6) in 22 human tissues.