Prioritization of pathogenic mutations in the protein kinase superfamily

BMC Genomics

Table 4 Performance of the classifier when the groups in which UniProt divides the protein kinase superfamily are considered individually

Group	Accuracy (%)	Precision (%)	Recall (%)	MCC
CMGC †	91.5	87.5	8.6	0.1
TKL †	68.7	70.5	70.9	0.4
TK †	71.3	69.7	68.3	0.4
RGC †	58.2	47.9	61.3	0.2
Atypical_PI3-PI4 †	70.6	47.1	100	0.8
STE	96.8	43.7	11.1	0.1
AGC †	90.8	43.3	61.1	0.5
Other	88.9	41.6	95.4	0.9
CK1	97.7	33.3	22.2	0.2
Atypical_Alpha-type	89.9	9.1	88.9	0.8
CAMK †	55.5	8.3	51.9	0.1
Atypical_ADCK	70.0	0	0	0
NEK	100	0	0	0
Atypical_RIO	100	0	0	0
Atypical_PDK-BCKDK	100	0	0	0
Atypical_FAST	100	0	0	0

Performance of the classifier when the groups in which UniProt divides the protein kinase superfamily are considered individually. Groups enriched in disease-associated mutations are indicated by †.

ISSN: 1471-2164