| |
MCC
|
Accuracy
|
Specificity
|
Sensitivity
|
|---|
|
Global*
|
0.19
|
0.54
|
0.76
|
0.44
|
|
Minimum°
|
0.23
|
0.54
|
0.85
|
0.34
|
|
Maximum°
|
0.36
|
0.68
|
0.69
|
0.68
|
|
Average°
|
0.25
|
0.62
|
0.80
|
0.5
|
|
Random^
|
0.25
|
0.60
|
0.68
|
0.55
|
- *Global uses all data neglecting the correspondence between proteins and their conformers. °Minimum, Maximum and Average characterize the values of ΔΔG per SAS taking into account the conformers for each protein. ^Random MCC was calculated as an average over 50 independent selections of a randomly taken one ΔΔG value per SAS and per protein. In all the cases the threshold is ± 2kcal/mol. The difference between MCC values for Maximum and Random is significant at P-value=0.02. For definition of the different scoring indexes see text.
