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Table 1 Scoring the capability of discriminating among disease related and neutral SASs on different set of conformers.

From: On the effect of protein conformation diversity in discriminating among neutral and disease related single amino acid substitutions

  MCC Accuracy Specificity Sensitivity
Global* 0.19 0.54 0.76 0.44
Minimum° 0.23 0.54 0.85 0.34
Maximum° 0.36 0.68 0.69 0.68
Average° 0.25 0.62 0.80 0.5
Random^ 0.25 0.60 0.68 0.55
  1. *Global uses all data neglecting the correspondence between proteins and their conformers. °Minimum, Maximum and Average characterize the values of ΔΔG per SAS taking into account the conformers for each protein. ^Random MCC was calculated as an average over 50 independent selections of a randomly taken one ΔΔG value per SAS and per protein. In all the cases the threshold is ± 2kcal/mol. The difference between MCC values for Maximum and Random is significant at P-value=0.02. For definition of the different scoring indexes see text.