*Global uses all data neglecting the correspondence between proteins and their conformers. °Minimum, Maximum and Average characterize the values of ΔΔG per SAS taking into account the conformers for each protein. ^Random MCC was calculated as an average over 50 independent selections of a randomly taken one ΔΔG value per SAS and per protein. In all the cases the threshold is ± 2kcal/mol. The difference between MCC values for Maximum and Random is significant at P-value=0.02. For definition of the different scoring indexes see text.