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Table 3 Selected domains highly mutated in colon cancer tumor genomes

From: Domain landscapes of somatic mutations in cancer

Name Accession Mutations Cumulative Domain Length Genes (Number of Mutations)
APC_basic PF05956 5 356 APC (5)
APC_crr PF05923 8 176 APC (8)
CortBP2* PF09727 9 726 CTTNBP2NL (1), CTTNBP2 (2), FILIP1 (5), FILIP1L (1)
MH2 PF03166 14 731 SMAD4 (9), SMAD9 (2), SMAD2 (1), SMAD3 (1), GARS (1)
Miro PF08477 77 5861 KRAS (28), NRAS (7), RAB27B (2), RAB11B (2), RABL3 (2)
+ 46 genes with 36 additional mutations
MutS_IV PF05190 6 380 MSH4 (2), MSH6 (2), MSH5(1), MSH2 (1)
PI3K_p85B PF02192 4 231 PIK3CA (4)
P53 PF00870 28 390 TP53 (27), TP63 (1)
TAS2R PF05296 132 6557 TAS2R43 (36), TAS2R31 (31), TAS2R30 (25), TAS2R19 (21)
+ 19 genes with 27 additional mutations
WAP PF00095 6 299 WFDC8 (3), SLPI (1), WFDC5 (1), KAL1 (1)
  1. Selected list of significantly mutated domains as identified by LFDR (threshold < 0.1) of the mutation frequencies normalized by the cumulative domain length for all domains. The domain name and Pfam domain accession are provided. Mutation counts are the total counts of somatic mutations identified in 100 colon cancer patients which occur inside the associated protein domain region. Cumulative domain length is the cumulative amino acid length of all occurrences of a domain within all representative proteins for genes containing somatic mutations. The genes and associated mutation counts are listed for each gene containing mutations in the domain. The “*” next to the CortBP2 domain denotes that the domain did not reach the threshold for significant mutation frequency, but ranked in the top 75 highest mutation frequency domains.