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Table 1 Performance for optimizing the combination of two drugs.

From: Adaptive reference update (ARU) algorithm. A stochastic search algorithm for efficient optimization of multi-drug cocktails

 

Gur Game (simultaneous)

Gur Game (sequential)

Previous search algorithm[11](α= 1)

ARU algorithm (proposed) (α= 1)

 

success rate

unique comb.

success rate

unique comb.

success rate

unique comb.

success rate

unique comb.

f2a(x) : HIV INHIBITION

(M = 80)

97%

13.2

95%

17.2

100%

13.4

100%

12.1

f2b(x) : DE JONG (2ND)

(M = 441)

9%

3.6

10%

4.5

99%

56.2

99%

46.2

f2c(x) : CANCER INHIBITION

(M = 100)

58%

11.3

53%

13.0

98%

13.2

98%

12.4

f2d(x): BACTERIA INHIBITION

(M = 81)

96%

5.9

91%

6.8

100%

4.8

100%

4.5