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Table 1 Performance for optimizing the combination of two drugs.

From: Adaptive reference update (ARU) algorithm. A stochastic search algorithm for efficient optimization of multi-drug cocktails

  Gur Game (simultaneous) Gur Game (sequential) Previous search algorithm[11](α= 1) ARU algorithm (proposed) (α= 1)
  success rate unique comb. success rate unique comb. success rate unique comb. success rate unique comb.
f2a(x) : HIV INHIBITION (M = 80) 97% 13.2 95% 17.2 100% 13.4 100% 12.1
f2b(x) : DE JONG (2ND) (M = 441) 9% 3.6 10% 4.5 99% 56.2 99% 46.2
f2c(x) : CANCER INHIBITION (M = 100) 58% 11.3 53% 13.0 98% 13.2 98% 12.4
f2d(x): BACTERIA INHIBITION (M = 81) 96% 5.9 91% 6.8 100% 4.8 100% 4.5