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Table 3 Performance for optimizing the combination of two drugs in the presence of noise.

From: Adaptive reference update (ARU) algorithm. A stochastic search algorithm for efficient optimization of multi-drug cocktails

  Noise level Search type Performance metric Gur Game (simultaneous) Gur Game (sequential) Previous search algorithm[11](α= 1) ARU algorithm (proposed) (α= 1)
f2a(x) (2%) A success rate unique comb. 97% 96% 100% 100%
     12.5 17.0 13.3 11.6
   B success rate iterations 97% 95% 100% 100%
     37.8 45.2 25.8 20.0
  (5%) A success rate unique comb. 97% 96% 100% 100%
     12.6 17.1 13.3 11.8
   B success rate iterations 97% 95% 100% 100%
     38.0 45.4 26.6 20.2
  (8%) A success rate unique comb. 97% 96% 100% 100%
     12.6 17.0 13.3 12.0
   B success rate iterations 97% 95% 100% 100%
     38.2 45.4 26.8 20.4
f2b(x) (2%) A success rate unique comb. 10% 10% 99% 99%
     3.9 4.2 57.0 45.1
   B success rate iterations 10% 10% 99% 99%
     4.0 44 148.5 120.0
  (5%) A success rate unique comb. 9% 9% 98% 98%
     4.1 4.5 62.9 52.2
   B success rate iterations 9% 9% 98% 99%
     4.3 4.7 172.1 143.8
  (8%) A success rate unique comb. 8% 9% 97% 98%
     4.1 4.7 66.2 55.6
   B success rate iterations 9% 9% 97% 98%
     4.4 4.9 198.1 167.3
f2c(x) (2%) A success rate unique comb. 61% 54% 98% 98%
     10.9 12.7 13.1 12.5
   B success rate iterations 60% 54% 98% 98%
     33.1 36.0 35.9 35.2
  (5%) A success rate unique comb. 71% 66% 98% 98%
     11.4 13.2 12.9 12.4
   B success rate iterations 60% 54% 98% 98%
     33.2 35.4 36.7 36.0
  (8%) A success rate unique comb. 88% 83% 98% 98%
     11.7 13.4 12.6 12.0
   B success rate iterations 6.% 54% 98% 98%
     33.4% 34.3 37.4 37.0
f2d(x) (2%) A success rate unique comb. 100% 100% 100% 100%
     4.9 6.0 4.6 4.1
   B success rate iterations 96% 9.% 100% 100%
     18.3 19.7 8.2 7.7
  (5%) A success rate unique comb. 100% 100% 100% 100%
     4.9 5.7 4.3 4.1
   B success rate iterations 96.% 91% 100% 100%
     18.4 19.6 8.1 7.5
  (8%) A success rate unique comb. 100% 100% 100% 100%
     4.8 5.6 4.4 4.2
   B success rate iterations 96% 91% 100% 100%
     18.6 19.6 8.1 7.1