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Table 6 Performance for optimizing the combination of five drugs in the presence of noise.

From: Adaptive reference update (ARU) algorithm. A stochastic search algorithm for efficient optimization of multi-drug cocktails

 

Noise level

Search type

Performance metric

Gur Game (simultaneous)

Gur Game (sequential)

Previous search algorithm[11](α= 1)

ARU algorithm (proposed) (α= 1)

f5a(x)

(2%)

A

success rate unique comb.

8%

9%

100%

100%

    

2.1

4.4

139.3

122.5

  

B

success rate iterations

9%

11%

100%

100%

    

2.1

6.0

172.4

154.9

 

(5%)

A

success rate unique comb.

9%

11%

100%

100%

    

3.9

7.9

142.1

129.1

  

B

success rate iterations

9%

12%

100%

100%

    

108.3

38.6

177.1

155.6

 

(8%)

A

success rate unique comb.

10%

13%

100%

100%

    

7.1

20.2

144.5

131.4

  

B

success rate iterations

9%

13%

100%

100%

    

191.4

70.8

182.3

156.5

f5b(x)

(2%)

A

success rate unique comb.

89%

55%

100%

100%

    

917.9

1026.3

407.1

343.9

  

B

success rate iterations

90%

55%

100%

100%

    

999.8

1325.1

516.5

444.3

 

(5%)

A

success rate unique comb.

90%

59%

97%

98%

    

932.8

1002.7

507.7

463.6

  

B

success rate iterations

90%

56%

99%

99%

    

1004.7

1332.7

656.9

562.4

 

(8%)

A

success rate unique comb.

91%

59%

97%

98%

    

959.5

971.2

578.8

534.8

  

B

success rate iterations

90%

56%

99%

99%

    

1015.2

1341.0

735.0

668.6