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Table 6 Performance for optimizing the combination of five drugs in the presence of noise.

From: Adaptive reference update (ARU) algorithm. A stochastic search algorithm for efficient optimization of multi-drug cocktails

  Noise level Search type Performance metric Gur Game (simultaneous) Gur Game (sequential) Previous search algorithm[11](α= 1) ARU algorithm (proposed) (α= 1)
f5a(x) (2%) A success rate unique comb. 8% 9% 100% 100%
     2.1 4.4 139.3 122.5
   B success rate iterations 9% 11% 100% 100%
     2.1 6.0 172.4 154.9
  (5%) A success rate unique comb. 9% 11% 100% 100%
     3.9 7.9 142.1 129.1
   B success rate iterations 9% 12% 100% 100%
     108.3 38.6 177.1 155.6
  (8%) A success rate unique comb. 10% 13% 100% 100%
     7.1 20.2 144.5 131.4
   B success rate iterations 9% 13% 100% 100%
     191.4 70.8 182.3 156.5
f5b(x) (2%) A success rate unique comb. 89% 55% 100% 100%
     917.9 1026.3 407.1 343.9
   B success rate iterations 90% 55% 100% 100%
     999.8 1325.1 516.5 444.3
  (5%) A success rate unique comb. 90% 59% 97% 98%
     932.8 1002.7 507.7 463.6
   B success rate iterations 90% 56% 99% 99%
     1004.7 1332.7 656.9 562.4
  (8%) A success rate unique comb. 91% 59% 97% 98%
     959.5 971.2 578.8 534.8
   B success rate iterations 90% 56% 99% 99%
     1015.2 1341.0 735.0 668.6