Figure 1

A framework representing regulatory relationship macrophage activation post-MI. Myocytes and monocytes are two inputs as shown in the blue dotted box. The red dotted box denotes outputs of the system, including M1 and M2 densities. Secretion function is denoted by thick arrow, activation and differentiation are denoted by thin arrow. The regulatory relationship shown in the framework was determined by published results [3, 13–17].