Figure 1

Indiscernibility example. Calculating target gene-centric (ρ) hypergeometric distribution cannot discern the completely different targeting topologies between (A) and (B) and between (C) and (D), resulting the same p-values (p = 0.30325 and 0.31120), respectively. The target link-centric (τ p-values can discriminate (A) and (B) (i.e., p = 0.62358 and 0.00956, respectively) and the miRNA-centric (μ p-values can discriminate (C) and (D) (i.e., p = 0.00695 and 0.65253, respectively). *p < 0.05, hypergeometric test.