MicroRNA-centric measurement improves functional enrichment analysis of co-expressed and differentially expressed microRNA clusters

Table 2 Comparison of miRNA-centric μ and gene-centric ρ measures^a

GO terms	ρ _i	ρ _j	ρ _k	ρ _l	p- value_ρ(rank)
	μ _i	μ _j	μ _k	μ _l	p -value _μ (rank)
GO:0033137, negative regulation	3	7485	0	10148	0.0765 (299)
of peptidyl-serine phosphorylation	6	0	282	265	0.0195 (14)
GO:0006474, N-terminal protein	3	7485	0	10148	0.0765 (299)
amino acid acetylation	6	0	320	227	0.0412 (28)
GO:0008054, cyclin catabolic	2	7486	2	10146	0.5668 (1842)
process	6	0	322	225	0.0427 (32)
GO:0031047, gene silencing by RNA	19	7460	6	10142	0.0006 (25)
	6	0	537	10	0.8958 (2566)
GO:0030335, positive regulation of cell migration	34	7454	16	10132	2.31e-04 (18)
	6	0	545	2	0.9783 (2879)
GO:0045944, positive regulation of	150	7338	112	10036	8.62e-07 (4)
transcription from RNA polymerase II promoter	6	0	546	1	0.9891 (2923)
GO:0006956, complement	1	7487	0	10148	0.4246 (1251)
activation	2	4	3	544	0.0010 (1)
GO:0060022, hard palate	1	7487	0	10148	0.4246 (1251)
development	4	2	85	462	0.0073 (3)
GO:0060123, regulation of growth	1	7487	0	10148	0.4246 (1251)
hormone secretion	4	2	87	460	0.0079 (4)
GO:0032926, negative regulation	3	7485	0	10148	0.07652 (286)
of activin receptor signaling pathway	5	1	226	321	0.0437 (35)
GO:0015936, coenzyme A	1	7487	1	10147	0.6689 (2086)
metabolic process	5	1	160	387	0.0102 (5)

^a The 'breast/up-regulated' miRNA cluster data from Volinia et al. (2006) using the target variation #6 (see Table 1) was used.

ISSN: 1471-2164