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Table 1 Rankings of known drug resistance determining genes

From: An approach to identifying drug resistance associated mutations in bacterial strains

   Rankings before prediction Rankings after prediction
gene id. drug name S WS OR S WS OR
tet Tetracycline 54.5 2.5 43.7 1.5 1.5 1.5
tetM Tetracycline 14.5 11.5 7.5 4 4 4
mecA Methicillin 1 1 1 1 1 1
mecA Oxacillin 3 4 2 1 2 1
ermA1 Clindamycin 5.5 5.5 5.5 1 1 1
ermC Clindamycin 907 471 907 414.5 11 191.5
ermA1 Erythromycin 3 3 4 1 1 1
ermC Erythromycin 1527 3994.5 1006.5 413.5 28 214.5
aacA-aphD Gentamicin 72 34 34 1 1 1
blaZ Penicillin 163 66 223 1.5 1 2.5
mecA Penicillin 163 8 223 11 5 52
Average ranking (excluding ermC): 53.27 15.05 60.411 2.55 1.94 7.22
  1. Rankings of the known drug resistance determinants obtained by employing three different methods to score gene gain/loss profiles: support (S), weighted support (WS) and odds ratio (OR). Since some of the gene gain/loss profiles are assigned with the same score, we calculate their rankings as the arithmetic mean of positions of the profiles with the same score on the list sorted according to the scores; thus some of the rankings are not round numbers. The rankings were computed before and after prediction of drug resistance, which is based on the presence of the drug resistance determinants. We excluded the gene ermC from the calculations of the rankings since none of the methods were able to pull it out into the top 100 before prediction.