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Table 7 Pathways significantly associated with top candidate genes by ToppFun.

From: Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study

Pathway ID/name Description Source p-value Terms in query Terms in genome
hsa04080 Neuroactive ligand-receptor interaction KEGG pathway 5.36 × 10-5 10 256
REACTOME_GPCR_LIGAND_BINDING Genes involved in GPCR ligand binding MSigDB: C2.cp - Reactome 2.66 × 10-3 10 392
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors MSigDB: C2.cp - Reactome 4.36 × 10-3 7 173
REACTOME_DOWNSTREAM_EVENTS_IN_GPCR_SIGNALING Genes involved in Downstream events in GPCR signaling MSigDB: C2.cp - Reactome 8.63 × 10-3 10 448
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors) MSigDB: C2.cp - Reactome 1.62 × 10-2 8 292
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signaling events MSigDB: C2.cp - Reactome 2.78 × 10-2 6 157