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Table 8 Mouse phenotypes significantly associated with top candidate genes by ToppFun.

From: Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study

Phenotype ID Phenotype name p-value Terms in query Terms in genome
MP:0009745 Abnormal behavioral response to xenobiotic 6.77 × 10-7 12 215
MP:0002206 Abnormal CNS synaptic transmission 4.31 × 10-6 14 382
MP:0003635 Abnormal synaptic transmission 3.57 × 10-5 14 450
MP:0002062 Abnormal conditioning behavior 6.87 × 10-5 10 199
MP:0002063 Abnormal learning/memory/conditioning 9.26 × 10-5 13 405
MP:0002065 Abnormal fear/anxiety-related behavior 1.05 × 10-4 10 208
MP:0001362 Abnormal anxiety-related response 3.59 × 10-4 9 179
MP:0002572 Abnormal emotion/affect behavior 8.34 × 10-4 11 329
MP:0001454 Abnormal cued conditioning behavior 1.41 × 10-3 6 66
MP:0003633 Abnormal nervous system physiology 2.44 × 10-3 20 1333
MP:0001399 Hyperactivity 2.57 × 10-3 9 226
MP:0001363 Increased anxiety-related response 2.86 × 10-3 7 117
MP:0009357 Abnormal seizure response to inducing agent 9.04 × 10-3 7 139
MP:0001449 Abnormal learning/memory 1.22 × 10-2 10 349
MP:0003088 Abnormal prepulse inhibition 1.45 × 10-2 5 57
MP:0003313 Abnormal locomotor activation 1.46 × 10-2 13 630
MP:0000950 abnormal seizure response to pharmacological agent 1.53 × 10-2 6 99
MP:0002945 Abnormal inhibitory postsynaptic currents 1.58 × 10-2 5 58
MP:0004008 Abnormal GABA-mediated receptor currents 2.85 × 10-2 3 11
MP:0009747 Impaired behavioral response to xenobiotic 3.45 × 10-2 5 68
MP:0004747 Abnormal cochlear OHC afferent innervation pattern 3.48 × 10-2 2 2