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Table 1 Bioinformatic target predictions for the subset of 20 microRNAs upregulated in osteogenic differentiation of USSC

From: MicroRNAs miR-26a, miR-26b, and miR-29b accelerate osteogenic differentiation of unrestricted somatic stem cells from human cord blood

 

hsa-miR-

 

Protein

Total

101

10a

137

152

192

22

26a

26b

29b

30b

30c

324-

337

345

483

501

532

590

598

660

            

3p

        

CDK6

6

x

 

x

  

x

x

x

x

           

CTNNBIP1

5

 

x

  

x

 

x

x

x*

           

AHSG

4

        

x

  

x

    

x

  

x

HDAC4

4

 

x

   

x

  

x*

    

x

      

CHRD

3

     

x

      

x

 

x

     

COL1A1

3

      

x

x

x

           

SOX2

3

      

x

x

         

x

  

COL4A2

2

      

x

 

x*

           

DUSP2

2

        

x*

          

x

HIPK2

2

      

x

x

            

NOG

2

   

x

x

               

SKI

2

        

x

        

x

  

SMAD7

2

x

    

x

              

SOSTDC1

2

      

x

x

            

STATH

2

x

 

x

                 

TGFB3

2

    

x

   

x*

           

TOB1

2

      

x

x

            

ACVR2A

1

    

x

               

AREG

1

             

x

      

COL5A3

1

        

x

           

SMAD6

1

        

x

           
  1. Bioinformatic target predictions for the subset of 20 miRNAs upregulated in osteogenic differentiation of USSC on osteo-inhibitory proteins: miR-26a, -26b, and -29b were experimentally assessed for impact on proteins denoted in bold. The second column (“Total”) illustrates the number of miRNAs from the analyzed set that targets an individual protein. Predictions with an asterix were already validated in the literature.