Figure 7
Characterization of CP genes in relation to the canonical TGFβ signaling pathway. The cellular localization of CP genes which function in the canonical TGFβ pathway was illustrated using IPA Path Designer. CP gene datasets uploaded to IPA were analyzed using default settings for the core analysis. A total of 19 CP transcripts from these datasets were associated with the TGFβ canonical pathway: ACVR1, BMP2, BMP4, BMP7, CREBBP, GRB2, INHBA, INHBB, KRAS, MAP2K1, MAP2K2, NKX2-5, RUNX2, SMAD3, TGFβ2, TGFβ3, TGFβR1, and TGFβR2. These datasets (n = 7) were selected and overlaid with each other using the IPA Path Designer. Color codes reflect the genotype and expression pattern of CP genes as follows: Orange lines: both TGFβ3−/−p1 and TGFΒβ3+/−p1; green filled: WTp1; light blue filled: WTp2; orange filled: WTp4; and purple filled: WTp8. The types of molecules are annotated in the legend.