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Figure 3 | BMC Genomics

Figure 3

From: A Drosophila functional evaluation of candidates from human genome-wide association studies of type 2 diabetes and related metabolic traits identifies tissue-specific roles for dHHEX

Figure 3

Diet-specific and tissue-specific lethality of dHHEX knockdown. A. tub P >RNAidHHEX-V15721flies tolerate many non-ideal diets, but are sensitive to high sucrose, as well as to glucosamine and to high salt. Estimates and confidence intervals (green: 95%, gray: Bonferroni-adjusted, N = 12) of ln(OR) are shown comparing odds of knockdown vs. non-knockdown animals pupariating compared to the genetic background control on that diet. More complete details are in Additional file 1: Table S3. B–C. tub P -GAL4, Dot-GAL4, and esg-GAL4 driving dHHEX knockdown using UAS-RNAidHHEX-V15721 confer lethality on high sucrose, but a number of other drivers do not. Estimates and confidence intervals (colored: 95%, gray: Bonferroni-adjusted, N = 11) of ln(OR) are shown for survival of knockdown vs. non-knockdown animals, compared to the genetic background control. Pupariation (unmarked) or eclosion (asterisks) or both were scored. More complete details are in Additional file 1: Tables S4 and S5.

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BMC Genomics

ISSN: 1471-2164

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