Inactivation of 11 lipid genes by RNAi in C . elegans displayed growth and developmental defects. RNAi of fasn-1 and pod-2 leads to severe larvae arrest. Inactivation of lpin-1, sams-1, fat-6, let-767, dhs-16, acs-1, K12H4.5, F25B4.6 and kat-1 resulted in slower growth. All images were captured using identical settings and exposure time. Worms grown on E. coli HT115 containing an empty vector were used as control. Bar, 200 μm.