The kinetic model of the protein interactome evolution. a. Schematic representation of proteome formation. b. Schematic representation of interactome formation. The symbols X and Y indicate the protein class. Other symbols indicate rates: f
- protein origination, k
- protein inactivation, k
- protein transition between classes, k
- protein duplication, f0ξ0/N - emergence of an interaction with a newborn protein, μ emergence of an interaction with an existing protein, Δμ- preference and r – loss of interaction.