Table 3 Candidate regulators in the Ribi group of eQTL hotspots

II:560 kb

TFC1

DNA binding

No

3 missense

RNA Pol III subunit

MAK5

Ribi

No

5 missense, 4 indel

60S ribosome processing

TBS1

DNA binding

6.7e-20

7 missense

Unknown

RPB5

Nucleolus

9.6e-3

promoter has 7 SNPs and 1 indel

RNA Poly subunit

CNS1

Protein folding

3.6e-9

promoter has 7 SNPs and 1 indel, 1 missense

TPR-containing co-chaperone

SMP1

DNA binding

2.7e-2

promoter has 7 SNPs and 2 indels

Transcription factor that regulates osmotic stress

MED8

DNA binding

1.2e-2

Promoter has 2 SNPs, 2 missense

RNA Poly II mediator complex

MCM7

DNA binding

No

6 missense

DNA ATPase activity

SDS24

Molecular function unknown

7.2e-7

2 missense, 2 promoter SNPs

Involved in cell separation during budding

ERT1

DNA binding

2.2e-2

5 missense, 8 SNPs in promoter and a 5 base insertion

Transcriptional regulator of nonfermentable carbon utilization

THI2

DNA binding

No

None

Zinc finger protein

ENP1

Ribi

No

None

40S ribosomal subunit synthesis

ISW1

DNA binding

No

1 missense

ATPase, DNA and nucleosome binding

REI1

Ribi

No

3 missense

Cytoplasmic pre-60S factor

V:350 kb

UTP7

Ribi

No

None

Processing of 18S rRNA

RAD51

DNA binding

No

None

Strand exchange protein

PBF2

Ribi

3.0e-2

9 missense

PAC binding factor

SWI4

DNA binding

No

2 missense

Transcriptional activator

V:420 kb

NSA2

Ribi

1.4e-5

None

Constituent of 60S pre-ribosomal particles

LCP5

Ribi

2.6e-3

1 missense

Involved in maturation of 18S rRNA

YER130C

DNA binding

No

1 missense

Unknown function

VII:70 kb

RAI1

Ribi

No

None

Required for pre-rRNA processing

RTF1

DNA binding

No

None

Subunit of RNA Pol II

KAP114

Protein import into nucleus

1.2e-8

9 missense

Karyopherin