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Table 4 Summary of knock-out results for candidate regulators in the Ribi group

From: Structured association analysis leads to insight into Saccharomyces cerevisiaegene regulation by finding multiple contributing eQTL hotspots associated with functional gene modules

 

ΔSDS24

ΔPBF2

ΔREI1

ΔRAI1

ΔKAP114

ΔSDS24HS

ΔPBF2HS

ΔREI1HS

ΔRAI1HS

ΔKAP114HS

% targets affected

4.7%

4.7%

74.4%

83.7%

4.7%

7.0%

79.1%

79.1%

86.0%

60.5%

max change

1.691

1.983

2.686

2.934

1.838

1.531

5.117

5.700

5.977

3.847

avg. change

1.168

1.245

1.641

1.824

0.962

1.174

2.206

2.241

2.417

1.641

# controls affected

0

0

3

2

1

0

1

5

3

1

p-value

1

1

8.6e-6

2.3e-8

1

0.55

1.3e-8

6.1e-5

7.6e-8

2.6e-5

  1. Genes with expression levels greater than 1.5 times the wild type, or less than 2/3 the wild type, levels are considered to be affected by the knockout. The max change and average change rows represent the fold change in the expression level compared to the wild time. HS denotes that the yeast were heat shocked before extracting RNA. There were 20 total control genes. The p-value represents a Fisher’s exact score between the genes affected in the target and control groups.
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BMC Genomics

ISSN: 1471-2164

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