Reductive evolution in Streptococcus agalactiaeand the emergence of a host adapted lineage

BMC Genomics

Table 2 Potential virulence factors in the ST260-261 strains

2-22	SS1219	90503	Gene	A909	Functional annotation	LPXTG¹	Ref	Mechanism of pathogenicity
pseudo²	GBS1219_1647	GBS90503_1646	cfa/cfb	SAK_1983	CAMP factor	no	[54]	*Pore-forming Toxins*
GBS222_0988-1005	GBS1219_979-0996	GBS90503_0979-0996	cps	SAK_1246-1263	Capsule synthesis enzymes	no	[55]	*Immune evasion*
GBS222_0661	GBS1219_0659	GBS90503_0659	sod	SAK_0913	Superoxide dismutase	no	[56]	*Immune evasion*
GBS222_0308	GBS1219_0307	GBS90503_0307	pbp1	SAK_0222	Penicillin-binding protein 1	no	[57]	*Resistance to host antimicrobial peptides*
GBS222_1019	GBS1219_1007	GBS90503_1007	pavA	SAK_1277	fibronectin/fibrinogen binding protein	no	[58]	*Adherence and invasion*
GBS222_0877³	GBS1219_0872³	GBS90503_08728³	fbsA	SAK_1142	Fibrinogen-binding protein A	yes	[51, 52]
GBS222_1210³	GBS1219_1192³	GBS90503_1192³	srr	SAK_1493	Serin-rich repeat protein	yes	[59]
GBS222_0182	GBS1219_0182	GBS90503_0182	sip	SAK_0065	Surface immunogenic protein	no	[60]
GBS222_1669³	GBS1219_1663³	GBS90503_1662³		SAK_2002	Surface protein, BibA family		[61]
GBS222_1026	GBS1219_1014	GBS90503_1014	hylB	SAK_1284	Hyaluronidase	no	[60, 62]
GBS222_0382	GBS1219_0382	GBS90503_0382		SAK_0502	surface protein	yes		*Cell-wall anchored proteins of unknown functions*
GBS222_0644	GBS1219_0646	GBS90503_0646		SAK_0896	surface protein	yes
GBS222_1220	GBS1219_1202	GBS90503_1202		SAK_1503	serine-rich surface protein	yes
GBS222_1221	GBS1219_1203	GBS90503_1203		SAK_1504	surface protein, Amidase family	yes

ISSN: 1471-2164