Figure 4

Modelling of the spatial arrangement of UTR over IGR space in P. falciparum . Schematics representing the two scenarios explored in this analysis are shown. In A) the UTR (double-headed arrows) apportioned over the central blue ORF (block arrow), need only fit in the total IGR space available on either side of this ORF. The apportionment is considered to fail only when the apportioned UTR overlaps with either adjacent ORF (eg. 10:90% transcript apportionment). In B) Scenario B is shown. Here the UTR for the blue ORF needs to fit into the IGR space available on either side of the ORF without overlapping with a similarly apportioned UTR over either flanking ORF (green and red block arrows). Examples of different apportionments of UTR are indicated to represent pass and fail. C) and D) Plots of the mean fail rate for the apportioned UTR (represented here as % apportioned to 5′ UTR) for all genes, using the indicated sizes of fixed length UTR, for Scenario A (C) and Scenario B (D).