Genome-wide association study of sleep in Drosophila melanogaster

BMC Genomics

Table 2 Candidate genes from this study with human homologues implicated in normal and disordered sleep

Human sleep trait or disorder	Human gene	Sleep trait	D. melanogastergene	References
Daytime sleepiness	PDE4D	Day average bout length	dunce (dnc)	[43]
		Night sleep CV_E
		Waking activity CV_E
	EYA1	Day average bout length	eyes absent (eya)	[43]
		Day bout number CV_E
Usual bedtime	OPCML	Day average bout length	CG31646	[43]
		Night sleep CV_E
		Waking activity CV_E
Sleep duration	NCOA7	Waking activity	l(3)82Fd	[43]
		Night sleep CV_E
		Waking activity CV_E
Narcolepsy	P2RY11	Day sleep CV_E	peter pan (ppan)	[44]
	TRIB2	Day bout number CV_E	tribbles (trbl)	[45–47]
				[48]
	Dscam	Day average bout length	Down syndrome cell adhesion molecule (Dscam)	[49]
Restless Leg Syndrome	MEIS1	Waking activity	homothorax (hth)	[50]
		Waking activity CV_E
	PTPRD	Waking activity CV_E	Leukocyte-antigen-related-like (Lar)	[51]
Sleep Apnea	ApoE	Night sleep	nudE	[52]
		Day average bout length
		Night sleep CV_E

ISSN: 1471-2164