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Table 1 Changes in rat brain cyp and arachidonate-related gene expression after traumatic brain injury

From: Temporal changes of cytochrome P450 (Cyp) and eicosanoid-related gene expression in the rat brain after traumatic brain injury

 

HIPPOCAMPUS, time postinjury:

CORTEX, time postinjury:

Gene name

6 h

24 h

72 h

168 h

6 h

24 h

72 h

168 h

 

A. Arachidonate-related Cyp s: mRNA fold-changes*

Cyp2c6

b

3.5x

  

b

b

b

b

Cyp2c22

 

3x

      

Cyp2c23

 

3x

      

Cyp2c54

b

3x

b

b

b

b

b

b

Cyp2e1

 

2.5x

      

Cyp2j3

   

2x

  

2x

[1.5x]

Cyp2j4

  

[2x]

4x

  

2x

[1.5x]

Cyp2u1

  

1.5x

2.5x

    

Cyp4a1

 

3x

      

Cyp4a8

2x

4x

7x

2x

    

Cyp4b1

[3x]

6x

5x

9x

2x

3x

4x

[1.5x]

Cyp4f5

  

1.5x

2x

  

[1.5x]

[1.5x]

Cyp4f6

  

1.5x

2x

    

Cyp4f18

    

3x

[2x]

[1.5x]

 

Cyp4x1

    

½x

½x

[½x]

½x

Cyp26b1

   

4x

   

2.5x

 

B. Eicosanoid-related genes: mRNA fold-changes*

Alox15

    

4x

[2x]

  

Ptgds2

  

6x

8x

  

5x

4x

Ptges

[2x]

[3x]

[3x]

11x

14.5x

[4.5x]

[1.5x]

[1.5x]

Ptgis

  

[1.5x]

3.5x

2x

1.5x

[2.5x]

[2.5x]

Ptgs1

  

6x

[½x]

  

2.5x

[½x]

Ptgs2

3x

 

[½x]

[½x]

5x

[3x]

  

Tbxas1

  

3x

5x

[3.5x]

[3x]

6x

[3.5x]

Ephx1

   

2x

    

Hpgd

 

1.5x

      

Lta4h

    

[1.5x]

 

2.5x

[1.5x]

Pla2g4a

[2x]

[2x]

3.5x

2.5x

2.5x

2.5x

5x

[2x]

Alox5ap

[2x]

[3x]

4x

4x

5x

[3x]

[3x]

 

Ptgfrn

1.5x

1.5x

1.5x

1.5x

    

Ptgdr_pred

  

[1.5x]

3x

  

[2.5x]

[2.5x]

Ptger2

2x

[1.5x]

3x

[2x]

[2x]

[2.5x]

[2.5x]

 

Ptger4

[2.5x]

[2.5x]

5x

7x

2.5

1.5x

2.5x

1.5x

Ptgir

6x

5x

3x

[2.5x]

4x

2.5x

[2x]

 
 

C. Other Cyp genes: mRNA fold-changes*

Cyp1a1

 

2.5x

1.5x

1.5x

    

Cyp1b1

  

3x

20x

5x

6.5x

3.5x

 

Cyp2a2

b

[~10x]

    

b

 

Cyp2r1

  

[1.5x]

2.5x

    

Cyp3a18

 

3x

      

Cyp7a1

b

4x

6.5x

8x

 

b

b

 

Cyp11b3

9.5x

8.5x

2.5x

     

Cyp17a1

  

3x

     

Cyp20a1

 

[2x]

[2x]

2.5x

    

Cyp24a1

    

~5.5x

~7x

b

 

Cyp27a1

[½x]

 

[3x]

9x

 

[½x]

[1.5x]

[2x]

Cyp27b1

   

2xª

~8x

~11x

b

[~2x]

  1. A: Arachidonate-related Cyps; B: Eicosanoid-related genes; C: Other Cyp genes. Gene expression assessed by qPCR is expressed as fold-change “x” compared to sham-operated controls at the same time point (i.e., 2-ΔΔCt). Only changes greater than 1.5x (or less than ½x) are shown. *p < 0.05, 2-way ANOVA, Tukey HSD (except where noted). Analyses performed on 2-ΔCt values of injured vs. sham at designated times after TBI (shown as fold-change rounded to the nearest ½x). ¶ p < 0.05, 1-way ANOVA with all shams combined as time zero. [x] brackets indicate changes ≥1.5-fold that were not statistically significant, but showed a trend (0.05 < p < 0.10). b Below the limit of quantification at these times. ~ Control (naïve, sham) values at or below limit of quantification, thus fold-change estimated based on highest control value(s).
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BMC Genomics

ISSN: 1471-2164

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