Backbone stability Vs Genome organization stability. Inset: the relationship between BS and GOS for all comparisons (intra- and inter-species). Main panel: markers correspond to the β coefficients of the regression model B S=α+β G O S for intra-species comparisons and the line their standard errors. The larger the β, the greater the importance of gene order rearrangements for genome organization evolution. A small coefficient indicates that genome content dynamics has a larger impact on genome evolution. Size of the marker is proportional to the average phylogenetic distance within a species. Species for which the quality of the regression is not good are in gray (see Additional file 3). The largest coefficients correspond to free-living species.