The role of microRNAs in the pathogenesis of MMPi-induced skin fibrodysplasia

BMC Genomics

Table 1 Correlation of miRNA expression, plasma PIIINP concentration and histological evidence of FD

miRNA	Correlation with Plasma PIIINP concentration (r)	Correlation with histopathological score (r)	First detection of significant regulation (Study Day)
cfa-miR-382	0.53	0.28	Day 17
cfa-miR-380	0.50	0.29	Day 17
cfa-miR-199	0.49	0.25	Day 17
cfa-miR-223	0.47	0.31	Day 14
cfa-miR-21	0.46	0.43	Day 11
cfa-miR-885	−0.36	−0.52	Day 11
cfa-miR-375	−0.34	−0.48	Day 17
cfa-miR-211	−0.27	−0.47	Day 17
cfa-miR-200c*	−0.25	−0.42	Day 17
cfa-miR-182	−0.25	−0.50	Day 17

Correlation of miRNA expression in the cervical subcutaneous tissue with plasma PIIINP concentration and histological evidence of fibrodysplasia. Data are r values for the top 10 most highly correlated miRNAs. This analysis was limited to those miRNAs previously identified as being significantly differentially expressed by global miRNA sequencing where P< 0.05 following FDR correction (N = 24).

ISSN: 1471-2164