Figure 7

ChIP-seq experiment with NEXT-peak model parameters. A genomic location of the center of the TF is denoted as μ. Green bi-directional arrows represent cross-links between a TF and a genomic sequence. Cross-links are assumed to be normally distributed with standard deviation σ. Tags are shown as small black rectangles at the 5′ end of fragments. The distance from a cross-link to a tag location is assumed to be exponentially distributed with mean β. When tags are mapped to a reference genome, then tags are projected onto the corresponding genomic locations. Blue arrows represent “left” tags mapped on the forward strand; red arrows, “right” tags mapped on the backward strand. The tag distribution is the NEXT-peak under the previous assumptions.