Skip to main content

Table 4 GO biological process representative of top ten overrepresented functional annotation clusters among genes overexpressed in embryos versus somatic cells at P < 0.001 and 10 FC

From: RNA-seq analysis of single bovine blastocysts

Biological process Gene count P value Genes
Chordate embryonic development 27 4.6E-6 HNF1B, CDX2, PTK7, CITED1, ZIC2, GATA2, DAB2, POU5F1, RSPO3, TDGF1, KRT8, HOXC5, AXIN2, GINS1, GSC, TBX3, ESRRB, NASP, GJB5, SLC34A2, CCNB1, HOXB4, GCM1, SALL4, PDGFRA, HOXB9, MYH10
Blastocyst development 6 0.007 GINS1, HNF1B, CDX2, ESRRB, POU5F1, NASP
Pattern specification process 16 0.002 NANOG, HNF1B, GSC, CDX2, TBX3, OTX2, ZIC3, TCF7L1, HOXB4, LHX2, FOXG1, HOXC5, TDGF1, HOXB9, HHIP, AXIN2
Negative regulation of gene expression 21 0.001 DNMT3A, NANOG, GSC, CDX2, TBX3, RCOR2, SOX2, MLXIPL, MAEL, CENPF, TNP1, LIN28A, PKIA, LIN28B, TCF7L1, HOXB4, SALL4, POU5F1, SOX15, DNMT3B, TDRD1
Placenta development 9 8.5E-4 GATA2, CDX2, GCM1, ESRRB, RSPO3, KRT8, GJB3, GJB5, CITED1
Cellular component morphogenesis 23 2.1E-5 CCDC99, ACTC1, NDN, ESRRB, PDPN, MYBPC3, KIF5C, PTK7, MAEL, SLITRK2, LAMA1, DAB2, BDNF, LAMB2, PRDM14, FAT1, LHX2, FOXG1, KRT8, SLITRK5, NEFL, MYH10, GFRA3
Stem cell maintenance 5 0.001 NANOG, CDX2, ESRRB, POU5F1, SOX2
Cell adhesion 24 0.005 TYRO3, CADM3, MPZL2, ATP1B2, CLSTN3, PDPN, CLDN6, MYBPC3, FERMT2, PTK7, BCAM, AMIGO2, LAMA1, LAMB2, DSG2, SORBS1, DSG3, PKP2, FAT1, FREM1, PECAM1, COL12A1, CNTNAP1, ESAM
Establishment of organelle localization 5 0.007 CCDC99, NPM1, CENPF, CDCA5, MYH10
Regulation of glucose metabolic process 4 0.003 HNF4A, SORBS1, MLXIPL, GNMT