Figure 6

Evolutionary conservation of residues of the VFT domain visualized on the comparative modeling of AmVKR based on mGluR5 crystal (PBP: 3lmkA). Structurally important motifs are indicated in red and residues composing the consensus amino-acid binding motif of VFT domains [24] are in green sticks (for details see Figure 5). The highly conserved residues S₆₆, E₉₂ and Y₄₀₆, found to be important for amino-acid binding, are localized within the binding pocket, together with two conserved structural residues T₁₀₈ and I₁₀₉ shown in red sticks.